VRAYLAR pharmacokinetics

Time to peak plasma concentration1

Charts of VRAYLAR pharmacokinetics. Time to peak plasma and half-life

~3–6 hours
After a single dose of
VRAYLAR 1.5 mg/day

~3–6 hours

After a single dose of VRAYLAR 1.5 mg/day

Half-life1

Charts of VRAYLAR pharmacokinetics. Time to peak plasma and half-life

~7 days
VRAYLAR plasma
concentration decreased by
~50% in approximately 1 week*

~7 days

VRAYLAR plasma concentration decreased by ~50% in approximately 1 week*

*After multiple dose administration of VRAYLAR, mean cariprazine and DCAR concentrations reached steady state at around Week 1 to Week 2 and mean DDCAR concentrations approached steady state around Week 4 to Week 8 in a 12-week study. The half-lives based on time to reach steady state were 2 to 4 days for cariprazine, ~1 to 2 days for DCAR, and approximately 1 to 3 weeks for DDCAR. The time to reach steady state for DDCAR was variable across patients, with some not achieving steady state at the end of the 12-week treatment. After discontinuation of VRAYLAR, mean plasma concentrations of cariprazine and DCAR decreased by ~50% in ~1 day, and mean plasma concentration of DDCAR decreased by ~50% 1 week after the last dose. The decline in plasma concentrations of active drug and metabolites may not be immediately reflected in patients’ clinical symptoms.1

DCAR=desmethyl cariprazine; DDCAR=didesmethyl cariprazine.