Pharmacodynamics1

VRAYLAR receptor-binding affinity1

Chart showing VRAYLAR receptor binding affinity.
The clinical significance of these in vitro data is unknown.

Ki (inhibitory constant) value represents the binding strength between a medication and a specific receptor.
The smaller the Ki value, the greater the binding affinity to that receptor.
No appreciable affinity for cholinergic muscarinic receptors (IC50 >1000 nM).

*dopamine D3 Ki value (nM): 0.085, dopamine D2L Ki value (nM): 0.49, dopamine D2S Ki value (nM): 0.69, serotonin 5-HT2B Ki value (nM): 0.58, serotonin 5-HT1A Ki value (nM): 2.6.

†serotonin 5-HT2A Ki value (nM): 18.8, histamine H1 Ki value (nM): 23.2.

‡serotonin 5-HT2C Ki value (nM): 134, α1A-adrenergic Ki value (nM): 155

nM=nanomolar.

The clinical significance of these in vitro data is unknown.
Ki (inhibitory constant) value represents the binding strength between a medication and a specific receptor.
The smaller the Ki value, the greater the binding affinity to that receptor.
No appreciable affinity for cholinergic muscarinic receptors (IC50 >1000 nM).

*dopamine D3 Ki value (nM): 0.085, dopamine D2L Ki value (nM): 0.49, dopamine D2S Ki value (nM): 0.69, serotonin 5-HT2B Ki value (nM): 0.58, serotonin 5-HT1A Ki value (nM): 2.6.

†serotonin 5-HT2A Ki value (nM): 18.8, histamine H1 Ki value (nM): 23.2.

‡serotonin 5-HT2C Ki value (nM): 134, α1A-adrenergic Ki value (nM): 155.

nM=nanomolar.