Do you have a patient with undiagnosed bipolar I depression in your practice?

Does this describe a patient you will see today?

Unresolved symptoms of depression*

A history of mania, which may include increased irritability, agitation, or racing thoughts/pressured speech3,4*

Some common risk factors*:

  • Tried multiple antidepressants5
  • First onset of depression in their 20s3
  • Family history of mood disorders3,6

This may clarify if you should…

Maintain current diagnosis or

Take a mood history to determine an appropriate diagnosis for the patient

 

The Mood Disorder Questionnaire (MDQ) is a mood screener that uses patient-reported answers to help uncover bipolar I disorder.7

If The Moment leads to a bipolar I depression diagnosis, VRAYLAR is an option proven to treat bipolar I depression.1

*These are common risk factors, not a complete list of diagnostic criteria. See DSM-5 for full diagnostic criteria.

 

No matter the bipolar I episode, VRAYLAR is approved to treat it1

Examples of symptoms most commonly seen in the office4,7-9

BIPOLAR I DEPRESSION3,10

Prolonged sadness

Changes in sleep or appetite

Pessimism or indifference toward pleasurable activities

Difficulty concentrating or with routine activities

Suicidal thoughts

TIME IN MOOD STATE WHEN SYMPTOMATIC12: 75%

MIXED3†

Mood and energy going in different directions

Feeling energetic while depressed

Having racing thoughts but unable to take action

TIME IN MOOD STATE WHEN SYMPTOMATIC12: 20%

BIPOLAR I MANIC3,11

Energy at odd hours

Little need for sleep

Racing thoughts or overly talkative

Sustained elevated, irritable, or panicked mood

Highly ambitious or impulsive

TIME IN MOOD STATE WHEN SYMPTOMATIC12: 5%

The approval of VRAYLAR for the treatment of bipolar I depression and acute manic or mixed episodes of bipolar I was based on the change from baseline in total score, not individual symptom measurement, on the MADRS and the YMRS, respectively.1

Mixed bipolar I is clinically defined in DSM as Mixed features (DSM-5): Manic episode + 3 or more depressive symptoms lasting ≥1 week or major depressive episode + 3 or more manic symptoms lasting ≥2 weeks; Mixed episode (DSM-IV-TR): Manic episode lasting ≥1 week + major depressive episode.3,13

DSM=Diagnostic and Statistical Manual of Mental Disorders; MADRS=Montgomery-Asberg Depression Rating Scale; TR=text revision; YMRS=Young Mania Rating Scale.